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专利名称：Methods of monitoring disease states and
therapies using gene expression profiles
发明人：Stephen H. Friend,Roland Stoughton申请号：US09783474申请日：20010214
公开号：US20010018182A1公开日：20010830
摘要：The present invention provides methods for monitoring disease states in asubject, as well as methods for monitoring the levels of effect of therapies upon asubject having one or more disease states. The methods involve: (i) measuring
abundances of cellular constituents in a cell from a subject so that a diagnostic profile isobtained, (ii) measuring abundances of cellular constituents in a cell of one or moreanalogous subjects so that perturbation response profiles are obtained which correlateto a particular disease or therapy, and (iii) determining the interpolated perturbationresponse profile or profiles which best fit the diagnostic profile according to someobjective measure. In other aspects, the invention also provides a computer systemcapable of performing the methods of the invention, data bases comprising perturbationresponse profiles for one or more diseases and/or therapies, and kits for determininglevels of disease states and/or therapeutic effects according to the methods of theinvention.
申请人：ROSETTA INPHARMATICS, INC.
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