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专利名称：Amides of creatine, method of their
preparation, and remedy possessing aneuroprotective activity
发明人：Sergej Vladimirovich Burov,Natalia Vasilyevna
Khromova,Anna AlexandrovnaKhromova,Petr Alekseevich Khromov
申请号：US12734183申请日：20081224公开号：US08350077B2公开日：20130108
摘要：The invention relates to pharmaceutical chemistry notably to new biologicallyactive substances (BAS) and their properties. In particular, the invention relates toCreatine derivatives having a general formula: NH═C(NH)—N(CH)—CH—CO—NH—R*X,wherein R—amino acid residue of aliphatic, aromatic or heteroaromatic L-amino acid or itsderivative representing a salts of amino acid, amino acid esters, amino acid amides orpeptides; X—lower organic or mineral acid or water. New substances are prepared byinteraction of aforesaid amides of sarcosine having a general formula of HN(CH)—CH—CO—NH—R*X, wherein: R is amino acid residue or substituted amino acid residue; X islow-molecular-weight organic acid or mineral acid or water, with a guanidinylating agentswith the in organic solvents at temperature not exceeding 50° C. New chemicalcompounds can be used as a remedy possessing a neuroprotective activity.
申请人：Sergej Vladimirovich Burov,Natalia Vasilyevna Khromova,Anna AlexandrovnaKhromova,Petr Alekseevich Khromov
地址：Saint-Petersburg RU,Saint-Petersburg RU,Saint-Petersburg RU,Saint-PetersburgRU
国籍：RU,RU,RU,RU
代理人：Aleksandr Smushkovich
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