CAL-130 Racemate_474012-90-3_DataSheet_MedChemExpress

Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :CAL-130 Racemate474012-90-3HY-16122426.47C23H22N8O>98%Solubility:DMSOMechanisms: Pathways:PI3K/Akt/mTOR; Target:PI3K gyBiological Activity:CAL-130 racemate is a novel phosphoinositide 3-kinase (PI3K) inhibitor. It is reported that combinedinhibition of PI3Kγ/δ as therapy for T cell acute lymphoblastic leukemia (T-ALL). IC50 value: Target: PI3K In the absence of PTEN phosphatase tumor suppressor function, PI3Kγ or PI3Kδ alone can supportleukemogenesis, whereas inactivation of both isoforms suppressed tumor formation. The reliance ofPTEN null T-ALL on the combined activities of PI3Kγ/δ was further demonstrated by the ability of adual inhibitor to reduce disease burden and prolong survival in mice as well as prevent proliferationpgppand promote activation of proapoptotic pathways in human tumors....References:[1]. Subramaniam Prem S, et al. Targeting nonclassical oncogenes for therapy in T-ALL. Cancer cell(2012), 21(4), 459-72. [2]. Hirsch E, et al. Cancer Cell. 2012 Apr 17;21(4):449-50. doi: 10.1016/j.ccr.2012.03.025. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr